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For instance, CB-839 (a glutaminase inhibitor) paired with cabozantinib (a multitarget TKI) (NCT03428217) is being tested in metastatic renal cell carcinoma, leveraging metabolic reprogramming to enhance TKI efficacy

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MiRNAs found in body fluids, including blood and urine, represent an important advance in biomarker discovery and may be useful noninvasive injury biomarkers in nonclinical and clinical studies